Trade name: Cotellic™
Cobimetinib is the generic name for the trade name drug

Cotellic™. In some cases, health care professionals may use the trade name Cotellic™ when referring to the generic drug name cobimetinib.

Drug type: Cobimetinib is a targeted therapy. It is an oral MEK kinase inhibitor - (For more detail see "How this drug works," below.)

What cobimetinib is used for :
  • For the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib. The cancer must be BRAF V600E- or BRAF V600L-positive as indicated by an FDA-approved test.

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How cobimetinib is given :
  • Cobimetinib is a pill, taken by mouth, once daily. It can be taken with or without food.
  • Cobimetinib is usually taken once faily for 21 days followed by a 7-day rest period (no drug) for a 28-day cycle.
  • Take cobimetinib exactly as prescribed.
  • Swalow cobimetinib tablets whole. Do not crush or dissolve tablet.
  • Do not change your dose or stop cobimetinib unless your health care provider tells you to.
  • If you miss a dose, skip the missed dose and take your next dose at your regular time.
  • Do not take more than 1 dose of cobimetinib at one time. Call your health care provider righ away if you take too much.

The amount of cobimetinib that you will receive depends on many factors, your general health or other health problems, and the type of cancer or condition being treated. Higher doses do not give better response and may cause increased toxicity. Your doctor will determine your dose and schedule.